ncRNA name | Cnga1 shRNA |
ncRNA Category | shRNA |
Disease name | retinitis pigmentosa (RP) |
Species | Mus musculus |
Tissues/Cell_line | retinas |
Methods | shRNA knockdown, H&E staining, immunoblot, ERG |
Expression pattern | associated |
Functional description | We tested a novel combination therapy using bipartite lentiviral vectors designed to both introduce wild-type PDE6β expression and knockdown GUCY2E or CNGA1. In Pde6b(H620Q) mutants, we observe rescue of photoreceptor function and an increase in photoreceptor rows as compared with untreated controls. |
PubMed ID | 21885480 |
Year | 2011 |
Title | Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa. |
Drug-related ncRNA | NA |
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